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Comparative analysis of cognitive functions and learning success in military cadets with vitamin D level in body: experimental sutyd

https://doi.org/10.22328/2413-5747-2024-10-4-103-110

Abstract

OBJECTIVE. Determine vitamin D status and its effect on cognitive functions and learning success in the fourth-year cadets.


MATERIALS AND METHODS. A pilot survey of 108 cadets (average age – 20 ± 1,4 years), studying in a military higher education institute of St. Petersburg, was conducted. Vitamin D body supply, the level of cognitive function development and success of learning activities were investigated. Vitamin D content was determined on a “Mindray” apparatus by enzyme immunoassay method. To assess the level of the development of cognitive functions, we have used tests aimed at diagnosing spatial figurative and verbal-logical thinking, memory and attention. The average grade for the year was considered as a criterion of success in learning activities.


RESULTS. When evaluating the level of vitamin D content, 31 (28,7 %) cadets experienced severe deficiency, 40 (37 %) – moderate deficiency, 21 (19,4 %) – mild deficiency and 16 (14,8 %) had its optimal level. No differences were found in the results of performing tests aimed at diagnosing thinking, memory and attention in cadets with deficient and optimal levels of vitamin D (p > 0,05). There has been direct correlation between learning success and vitamin D content in the body (p < 0,01).


DISCUSSION. The hypothesis about the effect of vitamin D concentration on level characteristics of thinking, memory and attention at a young age has not been confirmed. The results obtained are echoed in other studies aimed at investigating the effect of vitamin D supplementation on cognitive function in young healthy adults.


CONCLUSION. The study results have shown that low vitamin D status in young adults does not significantly affect the level characteristics of thinking, memory and attention. Vitamin D deficiency in young adults (on the example of military cadets) is a predictor of lower efficiency of cognitive functioning in the process of learning activity performance.

About the Authors

Dmitry S. Aganov
Military Medical Academy
Russian Federation

Cand. of Sci. (Med.), Lecturer of the Department of Faculty Therapy



Irina S. Svitsitskaya
Military Medical Academy
Russian Federation

Cand. of Sci. (Med.), associate professor of the Department of Faculty Therapy



Dmitry V. Ovchinnikov
Military Medical Academy
Russian Federation

Cand. of Sci. (Med.), Associate Professor


 



Elena O. Filippova
Military Medical Academy
Russian Federation

Researcher Associate, Military Medical Academy



Svetlana N. Levich
Military Medical Academy
Russian Federation

Senior Researcher



Alexey V. Yusupov
Military Medical Academy
Russian Federation

Cadet



References

1. Holick M. F. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Reviews in endocrine and metabolic disorders, 2017, Vol. 18, № 2, pp. 153–165. doi: 10.1007/s11154-017-9424-1.

2. Manson J. E., Brannon P. M., Rosen C. J., Taylor C. L. Vitamin D deficiency – is there really a pandemic? The New England journal of medicine, 2016, Vol. 375, № 19, pp. 1817–1820. doi: 10.1056/NEJMp1608005.

3. Shah D., Gupta P. Vitamin D deficiency: is the pandemic for real? Indian journal of community medicine, 2015, Vol. 40, № 4, P. 215–217. doi: 10.4103/0970-0218.164378.

4. Салухов В. В., Ковалевская Е. А., Курбанова В. В. Костные и внекостные эффекты витамина D, а также возможности медикаментозной коррекции его дефицита. Медицинский Совет. 2018. № 4. С. 90–99 [Salukhov V. V., Kovalevskaya E. A., Kurbanova V. V. Osteal and extraosteal effects of vitamin D and its opportunities of medication correction of its deficiency. Medical Council (Meditsinskiy sovet), 2018, (4), 90–99 (In Russ.)]. https://doi.org/10.21518/2079-701X-2018-4-90-99.

5. Rahman A., Al-Taiar A., Shaban L., et al. Plasma 25-hydroxy vitamin D is not associated with either cognitive function or academic performance in adolescents. Nutrients, 2018, Vol. 10, № 9, P. 1197. doi: 10.3390/nu10091197.

6. Saha S., Goswami R., Ramakrishnan L., et al. Vitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: Randomized control trial. Clinical endocrinology (Oxford), 2018, Vol. 88, № 2, pp. 217–226. doi: 10.1111/cen.13507.

7. Chen J., Mei K., Xie L., et al. Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19: a meta-analysis and GRADE assessment of cohort studies and RCTs. Nutrition journal, 2021, Vol. 20, № 1, P. 89. doi: 10.1186/s12937-021-00744-y.

8. Gnagnarella P., Muzio V., Caini S., et al. Vitamin D Supplementation and Cancer Mortality: Narrative Review of Observational Studies and Clinical Trials. Nutrients, 2021, Vol. 13, № 9, P. 3285. doi: 10.3390/nu13093285.

9. Scragg R., Stewart A.W., Waayer D., et al. Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin d assessment study: A randomized clinical trial. Journal of the American Medical Association cardiology, 2017, Vol. 2, № 6, pp. 608–616. doi: 10.1001/jamacardio.2017.0175.

10. Forman J. P., Bischoff-Ferrari H. A., Willett W. C., et al. Vitamin D intake and risk of incident hypertension: results from three large prospective cohort studies. Hypertension, 2005, Vol. 46, № 4, pp. 676–682. doi: 10.1161/01.HYP.0000182662.82666.37

11. Annweiler C., Dursun E., Féron F., et al. «Vitamin D and cognition in older adults»: updated international recommendations. Journal of internal medicine, 2015, Vol. 277, № 1, pp. 45–57. doi: 10.1111/joim.12279.

12. Etgen T., Sander D., Bickel H., et al. Vitamin D deficiency, cognitive impairment and dementia: a systematic review and meta-analysis. Dementia and geriatric cognitive disorders, 2012, Vol. 33, № 5, pp. 297–305. doi: 10.1159/000339702.

13. Balion C., Griffith L. E., Strifler L., et al. Vitamin D, cognition, and dementia: a systematic review and meta-analysis. Neurology, 2012, Vol. 79, № 13, pp. 1397–1405. doi: 10.1212/WNL.0b013e31826c197f.

14. Лобзин В.Ю., Емелин А.Ю., Алексеева Л.А. Ликворологические биомаркеры нейродегенерации в ранней диагностике когнитивных нарушений // Вестник Российской военно-медицинской академии. 2013. № 4. С. 15–20 [Lobzin V. Yu., Emelin A. Yu., Alekseeva L. A. Cerebrospinal fluid biomarkers of neurodegeneration in early diagnosis of cognitive impairment. Bulletin of the Russian Military Medical Academy, 2013, (4), 15–20. (in Russ.)].

15. Goodwill A. M., Szoeke C. A Systematic Review and Meta-Analysis of The Effect of Low Vitamin D on Cognition. Journal of the American Geriatrics Society, 2017, Vol. 65, № 10, pp. 2161–2168. doi: 10.1111/jgs.15012.

16. Llewellyn D. J., Lang I. A., Langa K. M., et al. Vitamin D and risk of cognitive decline in elderly persons. Archives of internal medicine, 2010, Vol. 170, № 13, pp. 1135–1141. doi: 10.1001/archinternmed.2010.173

17. Matchar D. B., Chei C. L., Yin Z. X., et al. Vitamin D levels and the risk of cognitive decline in Chinese elderly people: the Chinese longitudinal healthy longevity survey. The journals of gerontology. Series A, Biological sciences and medical sciences, 2016, Vol. 71, № 10, pp. 1363–1368. doi: 10.1093/gerona/glw128.

18. Bartali B., Devore E., Grodstein F., Kang J. H. Plasma vitamin D levels and cognitive function in aging women: the nurses’ health study. Journal of nutrition, health, and aging, 2014, Vol. 18, № 4, pp. 400–406. doi: 10.1007/s12603-013-0409-9.

19. Maddock J., Geoffroy M. C., Power C., Hyppönen E. 25-Hydroxyvitamin D and cognitive performance in mid-life. The British journal of nutrition, 2014, Vol. 111, № 5, pp. 904–914. doi: 10.1017/S0007114513003176.

20. van Schoor N. M., Comijs H. C., Llewellyn D. J., Lips P. Cross-sectional and longitudinal associations between serum 25-hydroxyvitamin D and cognitive functioning. International psychogeriatrics, 2016, Vol. 28, № 5, pp. 759–768. doi: 10.1017/S1041610215002252.

21. Overman M. J., Pendleton N., O’Neill T. W., et al. Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study. European journal of nutrition, 2017, Vol. 56, № 6, pp. 2093–2103. doi: 10.1007/s00394-016-1247-4.

22. Schneider A. L., Lutsey P. L., Alonso A., et al. Vitamin D and cognitive function and dementia risk in a biracial cohort: the ARIC Brain MRI Study. European journal of neurology, 2014, Vol. 21, № 9, pp. 1211–1218. e69–70. doi: 10.1111/ene.12460.

23. Slinin Y., Paudel M. L., Taylor B. C., et al. 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men. Neurology, 2010, Vol. 74, № 1, pp. 33–41. doi: 10.1212/WNL.0b013e3181c7197b.

24. Пигарова Е. А., Рожинская Л. Я., Катамадзе Н. Н. и др. Распространенность дефицита и недостаточности витамина D среди населения, проживающего в различных регионах Российской Федерации: результаты 1-го этапа многоцентрового поперечного рандомизированного исследования // Остеопороз и остеопатии. 2020. Т. 23, № 4. С. 4–12 [Pigarova E. A., Rozhinskaya L. Ya., Katamadze N. N., et al. Prevalence of vitamin D deficiency in various regions of the Russian Federation: results of the first stage of the multicenter cross-sectional randomized study. Osteoporosis and Bone Diseases, 2020, 23(4), 4–12 (In Russ.)]. https://doi.org/10.14341/osteo12701.

25. Bailey K. R. F., Pettersen J. A. Vitamin D is associated with visual memory in young northern adolescents. Nutritional neuroscience, 2023, № 8, pp. 1–12. doi: 10.1080/1028415X.2023.2199498.

26. Пигарова Е. А., Рожинская Л. Я., Белая Ж. Е. и др. Клинические рекомендации Российской ассоциации эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых // Проблемы эндокринологии. 2016. Т. 62, № 4. С. 60–84 [Pigarova E. A., Rozhinskaya L. Ya., Belaya Zh. E., et al. Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults. Problems of Endocrinology, 2016, 62, (4), 60–84 (In Russ.)]. doi: 10.14341/probl201662460-84.

27. Шадриков В. Д. Психология деятельности человека. М.: Институт психологии РАН. 2013. 464 с. [Shadrikov V. D. Psycology of human activity. Мoscow: Institute of Psychologe RAN, 2013, 464 p. (In Russ.)].

28. Дин А. Дж., Беллгроув М. А., Холл Т., Фан В. М. Дж., Эйлс Д. В. и др. Влияние добавок витамина D на когнитивные и эмоциональные функции у молодых людей —рандомизированное контролируемое исследование // PLoS ONE, 2011, № 6 (11), e25966 [Dean А. G., Bellgrow М. А., Holl Т., Fan V. M. G., Eyles D. W., et al. Effect of vitamin D supplementation on cognitive emotional functions in young people – randomized controlled trials. PLoS ONE, 2011, № 6, (11), e25966 (In Russ.)]. doi:10.1371/journal.pone.0025966.


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For citations:


Aganov D.S., Svitsitskaya I.S., Ovchinnikov D.V., Filippova E.O., Levich S.N., Yusupov A.V. Comparative analysis of cognitive functions and learning success in military cadets with vitamin D level in body: experimental sutyd. Marine Medicine. 2024;10(4):103-109. (In Russ.) https://doi.org/10.22328/2413-5747-2024-10-4-103-110

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