Interpretation of clinical blood tests. Part 3. Monocytes
https://doi.org/10.22328/2413-5747-2025-11-2-7-14
EDN: ALNNCQ
Abstract
Monocytes are the most important participants in the reactions of innate immunity, mechanisms of tissue damage and repair in cancer, cardiovascular and other diseases. Their evaluation is essential in various pathologic processes. Modern automated blood analysis allows not only to measure the absolute and relative content of these cells, but also to obtain additional information.
The lecture deals with monocytic parameters - the number of monocytes, mean monocyte volume (MMV), their volume distribution width (MDW) and other characteristics in various pathologies. The use of flow cytometry makes it possible to obtain data on the cell population of monocytes - average intensity of direct and lateral light scattering of monocytes, average fluorescence intensity, width of light scattering and fluorescence distribution (MO-X, MO-Y, MO-Z, MO-WX, MOWY, MO-WZ). The article shows the changes of the mentioned parameters in different pathology (sepsis, COVID-19, etc.). Some attention is paid to monocyte indices (monocyte/lymphocyte ratio, systemic inflammatory response index - SIRI), which are considered by many authors to be biomarkers of inflammation and have prognostic value in sepsis and other diseases. Modern hematological analyzers expand the possibilities of assessing blood reactions in pathological processes and increase the level of significance of clinical conclusions based on the results of laboratory tests.
About the Authors
V. V. Bazarnyi
Ural State Medical University; Sverdlovsk Regional Clinical Hospital No. 1
Russian Federation
Russian Federation
Vladimir V. Bazarnyi – Dr. of Sci. (Med.), Professor, Honored Scientist of the Russian Federation, Director of the Institute of Fundamental Medicine; Scientific Director of the Laboratory Diagnostics Department
620028, Ekaterinburg, Repin Str., 3
620102, Ekaterinburg, Volgogradskaya Str., 189
N. F. Klimusheva
Ural State Medical University; Sverdlovsk Regional Clinical Hospital No. 1
Russian Federation
Russian Federation
Natalia F. Klimusheva – Dr. of Sci. (Med.), Deputy Chief Physician,; Associate Professor of the Department of Urology, Nephrology and Transplantology
620028, Ekaterinburg, Repin Str., 3
620102, Ekaterinburg, Volgogradskaya Str., 189
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For citations:
Bazarnyi V.V., Klimusheva N.F. Interpretation of clinical blood tests. Part 3. Monocytes. Marine Medicine. 2025;11(2):7-14. (In Russ.) https://doi.org/10.22328/2413-5747-2025-11-2-7-14. EDN: ALNNCQ
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