Sexual characteristics of genetic determination of human propensity to aggressive, suicidal and addcitve behavior: descriptive study

INTRODUCTION. A lot of biological, including genetic predictors of specific deviations are associated with gender. Previously performed own studies revealed stable combinations of genetic status indicators, fully correlated with aggressive, suicidal and addictive behavior. These behavioral deviations are the basis for social and criminal tension in society, which justifies the expediency of further study of their genetic etiology based on gender.

OBJECTIVE: describe genetic determination of male and female propensity to aggressive, suicidal and addictive behavior.

MATERIALS AND METHODS. The study involved 300 men and women, aged 18–25 of the Caucasian race, indigenous people of the Crimean Republic, Arkhangelsk and Volgograd regions. The study participants’ propensity to aggressive, suicidal and addictive behavior was evaluated using standard methods of psychological testing. Laboratory genetic study was carried out by polymerase chain reaction (PCR) in real time. SNP were investigated: rs6923492 (GRM1), rs4680 (COMT), rs1851048 (CACNA2D3-1), rs6777055 (CACNA2D3-2), rs2562456 (ZNF-LD), rs1800497 (DRD2), rs6280 (DRD3). Statistical data analysis was performed using the Kruskal-Wallis test

RESULTS. In SNP rs6923492 (GRM1) Т/С genotype shows a minimal indicator intensity of the propensity to aggressive, suicidal and addictive behavior in both men and women. С/С and Т/Т genotypes are equally characterized by relatively increased values of the analyzed indicators. А/А rs4680 (COMT) genotype is characterized by the minimum level of the studied deviation manifestations. Among G/G genotype carriers, indicators of the propensity to aggressive, suicidal and addictive behavior prevail only in the group of men. On the contrary, among G/А genotype representatives, the propensity to aggression and suicide is pronounced only in the group of women. The maximum level of alcoholism and tobacco smoking in the female sample is equally manifested in G/А and G/G genotype representatives. Regardless of gender, G/G rs1851048 (CACNA2D3-1) genotype carriers are characterized by minimum, and G/А genotype carriers – maximum values of risk indicators of developing aggressive, suicidal and addictive behavior. In polymorphism rs6777055 (CACNA2D3-2) carriers of А/А genotype are characterized by minimum, and А/С genotype carriers – maximum expression of suicidality indicators among both men and women. А/А rs2562456 (ZNF-LD) genotype carriers are characterized by minimum intensity of single aggression indicators in men as well as indicators of aggression and suicidality in women. Genotypic analysis of SNP rs1800497 (DRD2) found a significant level of differences in indicators of aggressive and addictive behavior only in women between carriers of С/С (minimum values) and С/Т (maximum values) genotypes. Analysis of rs6280 (DRD3) polymorphism determined that maximum intensity of aggression and suicidality indicators is expressed in carriers of Т/С genotype regardless of gender. Indicators of the propensity to chemical addictions prevail additionally in women with Т/С genotype.

DISCUSSION. There are defined systemic connections between sexual identity, risk indicators of aggressive, suicidal and addictive behavior and analyzed polymorphisms and relevant human genotypes. It has been proven that the genetic status and person’s gender identity should be considered as the main factors of biological predisposition to deviant behavior.

CONCLUSION. As a result, the study has specified biological risks of forming aggressive, suicidal and addictive behavior, that would contribute to the development of effective measures to prevent deviant human behavior.

marine medicine, SNP, genotype, genetics of aggressive behavior, genetics of suicidal behavior, genetics of addictive behavior, genetic basis of risky behavior

1. Ohi K., Otowa T., Shimada M., et al. Shared genetic etiology between anxiety disorders and psychiatric and related intermediate phenotypes. Psychological Medicine, 2020, Vol. 50, No. 4, pp. 692–704. doi: https://doi.org/10.1017/S003329171900059X

2. Martin J., Taylor M. J., Lichtenstein P. Assessing the evidence for shared genetic risks across psychiatric disorders and traits. Psychological Medicine, 2018, Vol. 48, No. 11, pp. 1759–1774. doi:10.1017/S0033291717003440

3. Singh M. K., Gorelik A. J., Stave C., Gotlib I. H. Genetics, epigenetics, and neurobiology of childhood-onset depression: an umbrella review. Mol Psychiatry, 2024, Vol. 29(3), pp. 553–565. doi: 10.1038/s41380-023-02347-x

4. Gressier F., Calati R., Serretti A. 5-HTTLPR and gender differences in affective disorders: A systematic review. J Affect Disord, 2016, Vol. 15, pp. 193–207. doi: 10.1016/j.jad.2015.09.027

5. Seney M. L., Huo Z., Cahill K., et al. Opposite Molecular Signatures of Depression in Men and Women. Biol Psychiatry, 2018, Vol. 84(1), pp. 18–27. doi: 10.1016/j.biopsych.2018.01.017.

6. Mou J., Zheng T., Long Z., et al. Sex differences of brain cortical structure in major depressive disorder. Psychoradiology, 2023, Vol. 8(3), pp. 10–14. doi: 10.1093/psyrad/kkad014

7. Peng S., Zhou Y., Xiong L., et al. Identification of novel targets and pathways to distinguish suicide dependent or independent on depression diagnosis. Sci Rep, 2023, Vol. 13(1), pp. 24–88. doi: 10.1038/s41598-023-29101-1

8. Valentino R. J., Nair S. G., Volkow N. D. Neuroscience in addiction research. J Neural Transm (Vienna), 2024, Vol. 131(5), pp. 453–459. doi: 10.1007/s00702-023-02713-7

9. Mulik A. B., Shatyr Yu. A., Nazarov N. O., et al. Specification of Genetic-Based Systemic Manifestations of Human Tendency to Aggressive, Suicidal and Addiction Behavior. Scientific Notes of Crimean V. I. Vernadsky Federal University. Biology Chemistry, 2024, Vol. 10(76), No 2, pp. 128–143.

10. Батаршев А. В. Психодиагностика пограничных расстройств личности и поведения. М.: Институт психотерапии и клинической психологии. 2004. 320 с. [Batarshev A. V. Psychodiagnostics of borderline personality and behavior disorders. Moscow: Institute of Psychotherapy and clinical psychology, 2004, 320 p. (In Russ.)].

11. Козлов В. В., Мазилов В. А., Фетискин Н. П. Социально-психологическая диагностика развития личности и малых групп. Издание 2-е, дополненное и переработанное. М.: Институт психотерапии и клинической психологии, 2018. 720 с. [Kozlov V.V., Mazilov V.A., Fetiskin N.P. Socio-psychological diagnostics of personality development and small groups. Edition 2-e expanded and revised. Moscow: Institute of psychotherapy and clinical psychology, 2018, 720 p. (In Russ.)].

12. Шатыр Ю. А., Мулик И. Г., Улесикова И. В. и др. Оптимизация оценки выраженности и направленности социальной активности человека // Наука молодых (Eruditio Juvenium). 2017. Т. 5, № 4. С. 393–405 [Shatyr Y. A., Mulik I. G., Ulesikova I. V., et al. Optimization of the assessment of the severity and direction of human social activity. Science of the Young (Eruditio Juvenium), 2017, Vol. 5, No 4, pp. 393–405. (In Russ.)]. doi: 10.23888/HMJ20174393-405

13. Солдаткин В. А., Ковалев А. И., Крюкова М. Н. и др. Клиническая психометрика. Ростов-на-Дону: Издательство РостГМУ. 2020. 352 c. [Soldatkin V. A., Kovalev A. I., Kryukova M. N., et al. Clinical psychometrics. Rostov-on-Don: Rostov State Medical University Publishing House, 2020, 352 p. (In Russ.)].

14. Мулик А. Б., Шатыр Ю. А., Глушаков Р. И., и др. Психосоматические маркеры суицидальности // Профилактическая медицина. 2024. Т. 27, № 5. С. 84–91 [Mulik A. B., Shatyr Yu. A., Glushakov R. I., et. al. Psychosomatic markers of suicidality. Preventive medicine, 2024, Vol. 27, № 5, pp. 84–91 (In Russ.)]. https://doi.org/10.17116/profmed20242705184