Inhalation of heated oxigen-helium mixture in treating obstetrtic and gynecological pathology: prospective experimental study

INTRODUCTION. The heated oxygen-helium mixture has found application in treating acute respiratory failure in patients with the exacerbation of chronic obstructive pulmonary disease, postextubation stridor, croup and viral bronchiolitis in children, acute respiratory distress syndrome in newborns. The article presents the results of own study according to the results of applying inhalations of the heated oxygen-helium mixture (oxygen 30%, helium 70%) in order to improve reparative processes in postoperative gynecological cases (after myomectomy) and to treat placental insufficiency in pregnant women with diseases of the bronchopulmonary system.

OBJECTIVE. То estimate efficacy of the heated oxygen-helium mixture on the reproductive health of pregnant women with bronchopulmonary pathology and gynecological cases with patients of reproductive age after myomectomy.

RESULTS. Against the background of the treatment, there was an increase in blood oxygen saturation, normalization of indicators of fetoplacental hemodynamics and hormonal function of fetoplacental complex in pregnant women. Inhalations of the heated oxygen-helium mixture in gynecological cases after myomectomy led to an increase in blood flow velocity in the area of ligatures.

CONCLUSION. The study has shown that the method of inhalation through the heated oxygen-helium mixture (70% helium, 30% oxygen) is effective, safe and prospective for applying in obstetric and gynecological practice.

marine medicine, helium, oxygen-helium mixture, myomectomy, seam on uterus, bronchopulmonary disease, pregnancy, placental insufficiency, hypoxia

1. Barach A.L. Use of helium as a new therapeutic gas. Proc Soc Exper Biol and Med, 1934, Vol. 32, pp. 462–464. doi: 10.3181/00379727-32-7724P.

2. Barach A.L. The use of helium in the treatment of Asthma and obstructive lesions of the larynx and trachea. Ann.Intern. Med, 1935, Vol. 9, N 1, р. 735–765.

3. Павлов Б. Н., Плаксин С. Е. и др. Лечение подогреваемыми кислородно-гелиевыми смесями острых воспалительных и бронхообструктивных заболеваний легких с помощью аппарата «Ингалит». M., 2001 [Pavlov B. N., Plaksin S. E., et al. Treatment of acute inflammatory and broncho-obstructive pulmonary diseases with heated oxygen-helium mixtures using the Inhalit apparatus. Moscow, 2001 (In Russ.)].

4. Чучалин А. Г, Гусев В. И., Краснопольский В. И., Петрухин В. А и др. Протокол применения термического гелиокса в лечении больных с дыхательной недостаточностью (синдромом дыхательных расстройств). M., 2018, 47 с. [Chuchalin A. G., Gusev V. I., Krasnopolsky V.I., Petrukhin V.A., et al. Protocol for the use of thermal heliox in the treatment of patients with respiratory failure (respiratory distress syndrome). Moscow, 2018, 47 p. (In Russ.)]

5. Barnett T. B. Effects of helium and oxygen mixtures on pulmonary mechanics during airway constriction. J Appl Physiol. 1967, Vol. 22, pp. 707–713.

6. Alyamani O., et al. Inhalation of helium-oxygen mixture in two cases of maternal respiratory distress during labor and delivery. Anaesth Critic Care Med J. 2017, Vol. 2, № 1, 000120.

7. Mallet V. T., Bhatia R. K., Kissner D. G., Sokol R. J. Use of and HeO2 mixture in the management of apper airway obstruction during labor and delivery. J. Reprod Med, 1989, Vol. 34, № 6, 429–430.

8. George R., Berkenbosch J. W., Robert F. F. II, Tobias J. D. Mechanical ventilation during pregnancy using a helium-oxygen mixture in a patient with respiratory failure due to status asthmaticus reggie. Journal of Perinatology, 2001, Vol. 21, pp. 395–398.

9. Mallet V. T., Alyamani O., Bharadwaj Sh., Ihenatu Ch., Afrangui B., et al. The use of helium-oxygen mixture during labor and university of maryland school of medicine and delivery department of obstetrics, gynecology and reproductive sciences university of maryland school of medicineuse of an heo2 mixture in the management of upper airway obstruction during labor and delivery. A case report. J Reprod Med. 1989

10. Краснопольский В. И., Буянова С. Н., Щукина Н. А., Попов А. А. Оперативная гинекология. М.: МЕДпресс-информ. 2018. С. 320 [Krasnopol’skii V. I., Buyanova S. N., Shchukina N. A., Popov A. A. Operative gynecology. edition revised. Moscow: MEDpress-inform, 2018, pp. 320 (In Russ.)].