The effect of prenatal hypoxia on the manifestation of the ventilatory reaction of Wistar rats upon presentation of a hypoxic stimulus
https://doi.org/10.22328/2413-5747-2022-8-1-89-93
Abstract
The aim of the scientific work was to study the multidirectional effect of hypoxic sessions presented to pregnant rats at different periods of gestation on the manifestation of the ventilatory reaction of their offspring with dosed hypoxic hypoxia.
Materials and methods: a plethysmograph were used to record respiratory volume, respiratory rate and calculate the minute volume of respiration of intact rats (n=77) of the Wistar breed.
Results and discussion: presentation of a hypoxic stimulus to pregnant rats on certain days of gestation did not affect the gestation period, body weight and number of offspring, but changed the ventilatory response to hypoxia in males born and reached three months of age. Prenatal hypoxia, presented in the middle of pregnancy, led to a decrease in the ventilatory response to lack of oxygen in the offspring, and exposure of pregnant rats in hypoxic conditions at the end of the second trimester increased the ventilatory response to hypoxia.
About the Authors
A. N. Vjotosh
Sechenov Institute of Evolutionary Physiology and Biochemistry;
North-Western State Medical University named after I. I. Mechnikov;
Lesgaft National State University of Physical Education, Sport, and Health
Russian Federation
Russian Federation
St. Petersburg
O. S. Alexeeva
Sechenov Institute of Evolutionary Physiology and Biochemistry;
North-Western State Medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
St. Petersburg
A. I. Istomin
Sechenov Institute of Evolutionary Physiology and Biochemistry;
Lesgaft National State University of Physical Education, Sport, and Health
Russian Federation
Russian Federation
St. Petersburg
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Review
For citations:
Vjotosh A.N., Alexeeva O.S., Istomin A.I. The effect of prenatal hypoxia on the manifestation of the ventilatory reaction of Wistar rats upon presentation of a hypoxic stimulus. Marine Medicine. 2022;8(1):89-93. (In Russ.) https://doi.org/10.22328/2413-5747-2022-8-1-89-93
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