Mechanisms of violations of water-electrolyte metabolism under the influence of unfavorable factors of hyperbaria and promising possibilities of their correction

The purpose of the work: to identify the mechanisms of changes in kidney function and water-electrolyte metabolism in divers with different initial resistance to adverse factors of hyperbaria using oral stress renal tests.
Materials and methods. 44 men were examined. Initial resistance to adverse factors of hyperbaria was assessed in all subjects. To determine the state of kidney function, oral stress renal tests were performed under the influence of hypoxia, hyperoxia, toxic nitrogen concentrations and decompression gas formation.
Results and their discussion. Changes in kidney function and water-electrolyte metabolism occurring under the action of hyperbaria factors are largely determined by hormonal mechanisms implemented through the renin — angiotensin-aldosterone system (RAAS). Under the action of hypoxia, hyperoxia, toxic nitrogen concentrations and decompression gas formation on unstable subjects, the vector of changes in the activity of RAAS will mainly be directed towards increasing the secretion of antidiuretic hormone and aldosterone.

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