А case of heparin-induced thrombocytopenia in a patient with a novel coronaviral infection, features of diagnosis and treatment in a naval hospital conditions
https://doi.org/10.22328/2413-5747-2021-7-3-71-77
Abstract
The heparin-induced thrombocytopenia is a severe, potentially life-threatening complication of heparinotherpapia associated with thrombosis, develops as a result of antibody-mediated platelet activation. In the context of the SARS CoV-2 pandemic, the frequency of use of heparin in clinical practice has significantly increased, as a result of which the doctors have become more likely to face this complication. The article presents a review of the literature, describes the pathogenesis, modern algorithms for diagnosis and treatment, demonstrates a clinical case of heparin-induced thrombocytopenia in a patient with the SARS CoV-2, and discusses the features of diagnosis and treatment of this complication in a naval hospital.
About the Authors
I. D. Shapovalov
1477th Naval Hospital
Russian Federation
Russian Federation
Ilya D. Shapovalov.
Vladivostok.
V. E. Makarchenko
1477th Naval Hospital
Russian Federation
Russian Federation
Vladislav E. Makarchenko.
Vladivostok.
O. Yu. Kartina
1477th Naval Hospital
Russian Federation
Russian Federation
Oksana Yu. Kartina.
Vladivostok.
T. L. Belousova
1477th Naval Hospital
Russian Federation
Russian Federation
Tatyana L. Belousova.
Vladivostok.
References
1. Dudarenko S.V., Yezhova O.A. Heparin-induced thrombocytopenia. Emergency cardiology and cardiovascular risks, 2018, Vol. 2, No. 1, pp. 252-257 (In Russ.).
2. Semigolovsky N.Yu., Vavilova T.V., Kashchenko V.A., Semigolovsky S.N., Sapegin A.A. Heparin-induced thrombocytopenia in patients with venous thromboembolic complications — clinical observations and literature review. Medical Council, 2018, No. 5, pp. 110-116 (In Russ.).
3. Vasiliev S.A., Gorgidze L.A., Moiseeva T.N., Al-Radi L.S., Zozulya N.I., Sokolova M.A., Mazurov A.V. Heparin-induced thrombocytopenia (review). Atherothrombosis, 2019, No. 1, pp. 99-114 (In Russ.).
4. Dutkevich I.G., Sukhomlina E.N., Selivanov E.A. Fundamentals of Clinical Hemostasiology. St. Petersburg: Publishing house OOO IPK Costa, 2010, 144 p. (In Russ.).
5. Samsonova N.N., Klimovich L.G., Rogalskaya E.A. Pathogenesis of postoperative coagulopathies. Clinical physiology of blood circulation, 2014, No. 4, рр. 17-24 (In Russ.).
6. Marchenko I.A., Shiyan A.V., Andreeva A.S. Modern methods of laboratory diagnostics of heparin-induced thrombocytopenia. Medical Council, 2017, No. 12, pp. 189-195 (In Russ.).
7. Interim guidelines “Prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Version 9 (26.10.2020)” (approved by the Ministry of Health of Russia) (In Russ.).
8. Greinacher A., Warkentin T.E. Recognition, treatment, and prevention of heparin-induced thrombocytopenia: review and update // Thromb. Res. 2006. Vol. 118, No. 2. Р. 165-176.
9. Watson H., Davidson S., Keeling D. Guidelines on the diagnosis and management of heparin-induced thrombocytopenia: second edition // Br. J. Haematol. 2012. Vol. 159, No. 5. Р. 528-540.
10. Warkentin T.E. Heparin-induced thrombocytopenia: pathogenesis and management // Br. J. Haematol. 2003. Vol. 121, No. 4. Р. 535-555.
11. Linkins L.A., Dans A.L., Moores L.K., Bona R., Davidson B.L., Schulman S. et al. Treatment and prevention of heparin-induced thrombocytopenia. Antithrombotic Therapy and Prevention of Thrombosis. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. 9th ed. // Chest. 2012. Vol. 141. Р. 495-530.
12. Seigerman M., Cavallaro P., Itagaki S., Chung I., Chikwe J. Incidence and outcomes of heparin-induced thrombocytopenia in patients undergoing cardiac surgery in North America: An analysis of the nation — wide inpatient sample // J. Cardiothorac. Vasc. Anesth. 2014. Vol. 28. Р. 98-102.
13. Cucer A., Gowthami M.A., Beng H.C., Douglas B.C. ASH 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia // Blood Adv. 2018. Vol. 2, No. 22. Р. 3360-3392.
14. Lingamaneni P., Gonakoti S., Moturi K., Vohra I., Zia M. Heparin-Induced Thrombocytopenia in COVID-19 // J. Investig. Med. High Impact Case Rep. 2020. Jan-Dec. Vol. 8. 2324709620944091. doi: 10.1177/2324709620944091.
15. Sartori M., Cosmi B. Heparin-induced thrombocytopenia and COVID-19 // Hematol. Rep. 2021. Mar 12. Vol. 13, No. 1. Р. 8857. doi: 10.4081/hr.2021.8857. eCollection 2021 Mar 5.
Review
For citations:
Shapovalov I.D., Makarchenko V.E., Kartina O.Yu., Belousova T.L. А case of heparin-induced thrombocytopenia in a patient with a novel coronaviral infection, features of diagnosis and treatment in a naval hospital conditions. Marine Medicine. 2021;7(3):71-77. (In Russ.) https://doi.org/10.22328/2413-5747-2021-7-3-71-77
Views:
3
Email this article 
