METABOLIC CHANGES IN HUMANS UPON LONG-TERM CONTAINMENT IN AN ARGON-BASED HYPOXIC GAS MIXTURE
https://doi.org/10.22328/2413-5747-2018-4-2-7-14
Abstract
The objective of the present study was an in-depth assessment of the main human metabolic parameters upon longterm (60 days) containment in a normobaric argon-based hypoxic gas mixture (AHGM) for checking the possibility to develop gas media able to reduce the risk of ignitions and fires in inhabited sealed objects, such as submarines. Study group included six male subjects aged 20 to 51 years and found to be fit for sea trips lasting for up to 90 days. Continuing containment in the test medium comprising 30–35% V/V argon, 13,3–14,5% V/V oxygen, and up to 0,8% V/V, the rest being nitrogen, lasted for 60 days. During this time the subject were engaged in typical physical activities and operator routines. Venous blood samples were taken before, every 15 days in the course of, and 5 days after containment. This regimen has been found to be associated with the gradual accumulation of under-oxidized products of carbohydrate, protein and cholesterol metabolism in the blood and with increasing atherogenicity index. Adaptation to this regimen was manifested as decreases in the magnitudes of the above changes suggesting that metabolism may be tuned to increase body tolerance to hypoxia. Within 5 days after containment, virtually complete normalization of parameters studied was observed. The data confirm that it is possible to make gas mixtures for improving fire safety of inhabited sealed objects, in particular submarines.
About the Authors
A. O. Ivanov
Association of Developers and Manufacturers of Monitoring Systems
Russian Federation
Russian Federation
Andrey O. Ivanov
St. Petersburg
V. S. Petrov
Association of Developers and Manufacturers of Monitoring Systems
Russian Federation
Russian Federation
Vasiliy A. Petrov
St. Petersburg
E. N. Bezkishkiy
S. O. Makarov State University of Marine and Riverine Fleet
Russian Federation
Russian Federation
Eduard N. Bezkishkiy
St. Petersburg
A. Yu. Yeroshenko
Rostov State Medical University
Russian Federation
Russian Federation
Andrey Yu. Yeroshenko
Rostov-on-Don
N. V. Kochubeychik
Rostov State Medical University
Russian Federation
Russian Federation
Nikolay V. Kochubeychik
Rostov-on-Don
A. A. Ivanov
Medical service of the frigate «Admiral Kasatonov»
Russian Federation
Russian Federation
Anton A. Ivanov
Severomorsk
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Review
For citations:
Ivanov A.O., Petrov V.S., Bezkishkiy E.N., Yeroshenko A.Yu., Kochubeychik N.V., Ivanov A.A. METABOLIC CHANGES IN HUMANS UPON LONG-TERM CONTAINMENT IN AN ARGON-BASED HYPOXIC GAS MIXTURE. Marine Medicine. 2018;4(2):7-14. https://doi.org/10.22328/2413-5747-2018-4-2-7-14
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