SOME INNOVATIVE APPROACHES TO MAINTAINING THE ADAPTIVE RESPONSE OF THE ORGANISM UNDER STRESS
https://doi.org/10.22328/2413-5747-2018-4-1-85-95
Abstract
The paper presents data on the development of complex means, which increase the power of the adaptive response of the organism under stress and pathological conditions. This complex includes dietary supplements based on natural metabolites with pronounced antihypoxic activity, perfluorocarbon drugs for improving the oxygen regime of tissues, and effective immunomodulators based on sodium aminodihydrophthalazinedione and the neurotransmitter oligopeptide with increased stability. Their application is promising in the healthcare and in the military medicine. They provide an increase in efficiency, acceleration of recovery processes, increasing the body’s resistance to extreme loads, intoxications, infections, various types of tissue damage.
About the Authors
A. N. Tsar’kovRussian Federation
Serpukhov
S. V. Smurov
Russian Federation
Serpukhov
E. I. Maevsky
Russian Federation
Pushchino
I. V. Sedova
Russian Federation
Serpukhov
L. A. Bogdanova
Russian Federation
Pushchino
V. S. Volsky
Russian Federation
Serpukhov
M. V. Kozhurin
Russian Federation
St. Petersburg
References
1. Selye G. Na urovne celogo organizma: per. s angl. Moscow: Nauka, 1972, 122 р. (In Russ.).
2. Selye G. Ocherki ob adaptacionnom sindrome. Moscow: Medgiz, 1960, 254 р. (In Russ.).
3. Reestr lekarstvennyh sredstv Rossii. Spravochnik. Moscow, 2017 (In Russ.).
4. Maevskij E.I., Grishina E.V. Biohimicheskie osnovy mekhanizma dejstviya fumarat-soderzhashchih preparatov. Biomedicinskij zhurnal. 2017, Vol. 18, st. 2, рр. 59–80. (In Russ.).
5. Burnstock G., Verkhratsky A. Evolutionary origins of the purinergic signalling system. Acta physiologica (Oxford, England), 2009, Vol. 195, No. 4, рр. 415–447.
6. Murray J.M., Bussiere D.E. Targeting the purinome. Methods in molecular biology (Clifton N.J.). 2009, Vol. 575, рр. 47–92.
7. Hager Н. Rukovodstvo k Farmacevticheskoj i Mediko-himicheskoj praktik / per. s nem. pod red. i s dopolneniyami V.K. Alrena i A.V. Pelya. Vol. 1. Saint Petersburg: Izdanie K.L. Rikkera, 1887. Ahelomoschus — Capsulae. Ammonium Succinicum solutum. (In Russ.).
8. Terapevticheskoe dejstvie yantarnoj kisloty: sb. nauch. st. / pod red. M. N. Kondrashovoj. Pushchino. NCBI AN SSSR, IBF AN SSSR, Nauchnyj sovet po problemam biohimii zhivotnyh i cheloveka AN SSSR, 1976, 233 р. (In Russ.).
9. Yаntarnaya kislota v medicine, pishchevoj promyshlennosti, sel’skom hozyajstve: sb. nauch. statej / pod. red. M. N. Kondrashovoj, Yu. G. Kaminskogo, E. I. Maevskogo Pushchino: PNC RAN, PFK AO «Vnedrenie», ITEHB RAN, 1976. 300 р. (In Russ.).
10. Mitohondrii v patologii: materialy Vserossijskogo rabochego soveshchaniya / pod red. M. N. Kondrashovoj, Yu. G. Kaminskogo, E. I. Maevskogo. Pushchino: PNC RAN, ITEHB RAN, MNII pediatrii i detskoj hirurgii. MZ RF, 2001. 258 р. (In Russ.).
11. Dil’man V.M., Anisimov V.N., Kondrashova M.N. Vliyanie yantarnoj i glutaminovoj kislot na chuvstvitel’nost’ gipotalamo-gonadotropnoj sistemy k ingibiruyushchemu dejstviyu ehstrogenov u staryh krys. Farmakologiya i toksikologiya, 1976, Vol. 39, No. 5, рр. 540–543 (In Russ.).
12. Chen T.T., Maevsky E.I., Uchitel M.L. Maintenance of Homeostasis in the Aging Hypothalamus: The Central and Peripheral Roles of Succinate. Front. Endocrinol (Lausanne), 2015, No. 6, рр. 7. Published online: 2015 Feb 2. doi: 10.3389/fendo.2015.00007. PMCID: PMC4313775.
13. Kaken Kagaku Kabushiki Kaisha Succinic acid conformer and processes for preparing the same / Patent United Kingdom Patent No. 1063465, 1967. In Japan March 15. 1963.
14. Chidichimo G., Formoso P., Golemme A., Imbardelli D. Conformation of succinic acid: its pH dependence by Licry-NMR analysis. Molec. Physics., 1993, Vol. 79, No. 1, рр. 25–38.
15. He W., Miao F.J., Lin D.C., Schwandner R.T., Wang Z., Gao J. et al. Citric acid cycle intermediates as ligands for orphan G-proteincoupled receptors. Nature, 2004, Vol. 429, рр. 188–193.
16. Shustov E.B., Okovityj S.V. Ehks-orfannye receptory kak misheni dlya potencial’nyh lekarstvennyh sredstv. Biomedicina, 2015, No. 2, рр. 15–29. (In Russ.).
17. Koivunen P., Hirsilä M., Remes A.M., Hassinen I.E., Kivirikko K.I., Myllyharju J. Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. J. Biol. Chem., 2007, Vol. 282, рр. 4524–4532.
18. Yаkovlev N.N. Biohimiya sporta. Mosсow: Fizkul’tura i sport, 1974. 288 р. (In Russ.).
19. Kondrashova M.N., Chagovec N.R. Yаntarnaya kislota v skeletnyh myshcah pri intensivnoj deyatel’nosti i v period otdyha. Doklad Akademii nauk SSSR, 1971, Vol. 198, No. 1, рр. 243–246. (In Russ.).
20. Hochachka P., Somero Dzh. Strategiya biohimicheskoj adaptacii: per. s angl. Moscow: Mir, 1977. 398 р. (In Russ.).
21. Maevskij E.I., Rozenfel’d A.S., Grishina E.V., Kondrashova M.N. Korrekciya metabolicheskogo acidoza putem podderzhaniya funkcij mitohondrij. Pushchino, 2001. 155 р. (In Russ.).
22. Svidetel’stvo o gosudarstvennoj registracii № RU. 77.99.88.003.E.0036 26.08.16 ot 16.08.2016. (In Russ.).
23. Perftororganicheskie soedineniya v ehksperimental’noj i klinicheskoj medicine. Bibliograficheskij ukazatel’ 1966–2000 / pod red. G. A. Sofronova. Saint Petersburg, 2002. 215 р. (In Russ.).
24. Maevskij E.I. Vozmozhnye prichiny ostroj reaktogennosti ehmul’sij perftoruglerodov. Chast’ 1. Perftoran. Izvestiya Instituta inzhenernoj fiziki, 2016, No. 1 (39), рр. 79–87. (In Russ.).
25. Nedospasov A.A., Beda N.V. Perftoran — revolyucionnaya kombinaciya. Priroda, 2005, No. 8, рр. 33–38. (In Russ.).
26. Rafikova O., Sokolova E., Rafikov R., Nudler E. Control of Plasma Nitric Oxide Bioactivity by Perfluorocarbons. Physiological Mechanisms and Clinical Implications. Circulation, 2004, Vol. 110, рр. 3573–3580.
27. Moroz V.V, Maevskij E.I., Ivanickij G.R., Karmen N.B., Bogdanova L.A. et al. Ehmul’sii perftororganicheskih soedinenij kak sredstvo dlya lecheniya narushenij regionarnogo krovotoka. Obshchaya reanimatologiya, 2007, Vol. III, No. 3/1, рр. 49–53. (In Russ.).
28. Teoreticheskie aspekty primeneniya perftoruglerodov v medicine. Obshchaya reanimatologiya. Specializirovannyj vypusk, 2007, Vol. III, No. 3/1, рр. 8–37. (In Russ.).
29. Klinicheskoe primenenie perftoruglerodov. Obshchaya reanimatologiya. Specializirovannyj vypusk, 2007, Vol. III, No. 3/1, рр. 38–80. (In Russ.).
30. Manford R.S. Immuno-ehndokrinnye vzaimodejstviya. Fiziologiya ehndokrinnoj sistemy / pod red. D. Griffina, S. Ohedy; per. s angl. Moscow: Binom, 2008, рр. 114–128. (In Russ.).
31. Albert-Lőrincz Е., Albert-Lőrincz М., Kádár А., Krizbai Т., Lukács-Márton R. Romania Relationship between the Characteristics of the Psychological Immune System and the Emotional Tone of Personality in Adolescents. The new educational review. http://www.educationalrev.us.edu.pl/e23/a7.pdf.
Review
For citations:
Tsar’kov A.N., Smurov S.V., Maevsky E.I., Sedova I.V., Bogdanova L.A., Volsky V.S., Kozhurin M.V. SOME INNOVATIVE APPROACHES TO MAINTAINING THE ADAPTIVE RESPONSE OF THE ORGANISM UNDER STRESS. Marine Medicine. 2018;4(1):85-95. (In Russ.) https://doi.org/10.22328/2413-5747-2018-4-1-85-95