The features of tolerance to acute hypoxia by individuals with different levels of trait anxiety are presented. It was established that changes in such physiological parameters as heart rate in individuals with a high level of personal anxiety are more pronounced in hypoxic conditions. In particular, in this group, by the 25th minute of lifting in the altitude training chamber to a height of 5000 m, the heart rate increased by an average of 38.1% (p<0,01) of background values. In persons with a low level of trait anxiety, an increase in heart rate does not exceed an average 32% (p<0,01). However, in subjects with a high level of trait anxiety, compared with people with a low level of trait anxiety, a more pronounced increase in the Rufie index at an average of 18,2% (p<0,01). In addition, in individuals with a high level of trait anxiety, a more pronounced slowing-down time of a complex sensorimotor reaction by 33,0 ms (p<0,05) from the background value was observed, while in people with a low level of trait anxiety, on average, only by 20,2 ms (p<0,05). Thus, changes in individual physiological parameters in individuals with a high level of trait anxiety are more pronounced, their functional state is less tolerant to the hypoxia effect, and the level of physical performance is lower on average in this group.