seamedМорская медицинаMarine Medicine2413-57472587-7828Research Institute of Industrial and Maritime Medicine of the Federal Medical and Biological Agency10.22328/2413-5747-2018-4-2-38-47seamed-227Research ArticleОригинальные исследованияOriginal articlesТРУДНОСТИ РАННЕЙ ДИАГНОСТИКИ ЭОЗИНОФИЛЬНОГО ГРАНУЛЕМАТОЗА С ПОЛИАНГИИТОМ (СИНДРОМА ЧАРДЖАСТРОССА) В КЛИНИКЕ ВНУТРЕННИХ БОЛЕЗНЕЙDIFFICULTIES IN THE EARLY DIAGNOSIS OF EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (CHURGSTRAUSS SYNDROME) IN THE CLINIC OF INTERNAL DISEASESЧеркашинД. В.CherkashinD. V.

Черкашин Дмитрий Викторович — полковник медицинской службы, доктор медицинских наук, доцент, начальник кафедры военно-морской терапии 

194044, Санкт-Петербург, ул. Академика Лебедева, д. 6

Dmitrij V. Cherkashin

St. Petersburg

ТурдиалиеваС. А.TurdialievaS. A.

Турдиалиева Саёра Абдуалиевна — кандидат медицинских наук, доцент, доцент кафедры военно-морской терапии 

194044, Санкт-Петербург, ул. Академика Лебедева, д. 6

Sayora A. Turdialieva 

St. Petersburg

turdialieva@mail.ruМожаровскаяЕ. А.MozharovskayaE. A.

Можаровская Елена Анатольевна — заведующая амбулаторно-консультативным отделением 

190068, Санкт-Петербург, Большая Подъяческая ул., д. 30

Elena A. Mozharovskaya 

St. Petersburg

КудринаО. М.KudrinaO. M.

Кудрина Ольга Михайловна — кандидат медицинских наук, доцент, доцент кафедры военно-морской терапии 

194044, Санкт-Петербург, ул. Академика Лебедева, д. 6

Ol’ga M. Kudrina  

St. Petersburg

ТарановА. И.TaranovA. I.

Таранов Андрей Иванович — кандидат медицинских наук, доцент, ассистент кафедры военно-морской терапии 

194044, Санкт-Петербург, ул. Академика Лебедева, д. 6

Andrej I. Taranov 

St. Petersburg

Военно-медицинская академия им. С. М. КироваРоссияS. M. Kirov Military Medical AcademyRussian FederationКлиническая ревматологическая больница № 25РоссияClinical rheumatological hospital № 25Russian Federation201808072018423847Copyright © Черкашин Д.В., Турдиалиева С.А., Можаровская Е.А., Кудрина О.М., Таранов А.И., 20182018Черкашин Д.В., Турдиалиева С.А., Можаровская Е.А., Кудрина О.М., Таранов А.И.Cherkashin D.V., Turdialieva S.A., Mozharovskaya E.A., Kudrina O.M., Taranov A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://seamed.elpub.ru/jour/article/view/227

Systemic vasculitis are characterized by heterogeneity of clinical-immunological forms and determined the need for differential diagnostic search to except a wide range of diseases, such as allergic, infectious, hematological, oncological, which often presents significant difficulties for physicians of various specialties. The article presents clinical observations demonstrating the difficulties of diagnostic search in establishing the diagnosis of systemic vasculitis associated with antineutrophil cytoplasmic antibodies, which include a rare disease — eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome). Carefully collected anamnesis, participation of specialists of different profiles, retrospective analysis of laboratory and instrumental data allowed to verify the diagnosis, to prescribe adequate therapy. The aim of the publication is to discuss the need for early diagnosis of eosinophilic granulomatosis with polyangiitis, which can improve the effectiveness of therapy and improve the overall prognosis for this disease, taking into account modern approaches based on the main provisions of international recommendations that were prepared in 2015 with the participation of leading experts from Europe, USA and Canada and were called to become the basis for choosing a personalized patient therapy strategy.

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The authors declare that there are no conflicts of interest present.