seamedМорская медицинаMarine Medicine2413-57472587-7828Research Institute of Industrial and Maritime Medicine of the Federal Medical and Biological Agency10.22328/2413-5747-2017-3-4-95-103seamed-200Research ArticleИСТОРИЯ МОРСКОЙ МЕДИЦИНЫ. УКРЕПЛЕНИЕ РОССИЙСКИХ МОРСКИХ ТРАДИЦИЙHISTORY OF MARINE MEDICINE. CONSOLIDATING RUSSIAN MARINE TRADITIONSПРИМЕНЕНИЕ МЕТОДА ЭПР-СПЕКТРОСКОПИИ ДЛЯ ДИАГНОСТИКИ И ПРОГНОЗА ОНКОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙAPPLICATION OF ESR-SPECTROSCOPY FOR DIAGNOSIS AND PROGNOSIS OF CANCERSchnurrKerstinSchnurrKerstin

Medical Doctor (MD), Head of R&D team Medinnovation GmbH, Berlin, Germany. Groß-Berliner Damm

151б-12487 Berlin; tel.: (+49) 30-720-126-31

k.schnurr@medinnovation.deWaterstradtKatjaWaterstradtKatja

PhD, Head of laboratory Medinnovation GmbH, Berlin, Germany. Groß-Berliner Damm. 151б-12487, Berlin; tel.: (+49) 30-720-126-31

k.waterstradt@medinnovation.deMatthesGertMatthesGert

Medical doctor (MD), Head of transfusion Department, Institute of Transfusion Medicine, University Hospital Leipzig, Germany

gert.matthes@yahoo.deДмитриевП. Н.DmitrievP. N.

генеральный директор OOO «ЭПР Технологии»

121552, Москва, Островная ул., д. 2, офис 226; тел.: +7 (495) 234-52-47

p.dmitriev@medinnovation.deMedInnovation GmbHГерманияMedInnovation GmbHGermanyInstitute of Transfusion MedicineГерманияInstitute of Transfusion MedicineGermanyEPR TECHNOLOGIES LLCРоссияEPR TECHNOLOGIES LLCRussian Federation2017291220173495103Copyright © Schnurr K., Waterstradt K., Matthes G., Дмитриев П.Н., 20172017Schnurr K., Waterstradt K., Matthes G., Дмитриев П.Н.Schnurr K., Waterstradt K., Matthes G., Dmitriev P.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://seamed.elpub.ru/jour/article/view/200

Diagnostic medicine has significantly changed during the past decade. The emergence of proteomics and genomics has significantly increased our understanding of disease. These fields have also  revealed the vast array of proteins that are expressed in various  disease processes, such as cancer. Measurement of these unique  proteins expressed in certain diseases may offer diagnostic clues or  allow patient prognosis to be assessed. Another approach is to  measure the effects that these ligands have on the structure and function of albumin. Albumin is known to play an important role  in modulating the serum concentrations of various proteins produced by tumor cells. In this review, we introduce the reader to the  technique of spin labeling followed by electron paramagnetic  resonance spectroscopy. This method is a powerful tool for evaluating the structural and functional changes that can occur to albumin following the binding of various ligands. We describe the  utility of this technique for the diagnosis of cancer and sepsis, as  well as some other novel potential applications.

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The authors declare that there are no conflicts of interest present.