The  objective of the  present paper is to evaluate the  psychophysiological adaptation of freshmen to studying at Pacific  State Medical  University. The  habituation of freshmen to education is the  first and  most important task  of higher school. The  complexity and  specific  features of medical training present special challenges to  psychophysiological adaptation, which  warrant developing a dedicated training program. Its  outcomes were assessed using parameters that reflect the  general state, activity and  mood  as well as stress resistance and  socialization of freshmen and  subjected to statistical treatment. The  training program was  developed to teach techniques and  methods of self-regulation to freshmen thus making them able  to control their emotional and  physical conditions in professionally and  vitally important situations.