We analyzed the  age  criteria, time  of admission, comorbidities and  structure of chronic obliterating atherosclerosis therapy of lower  limb  arteries. It was  found that the  degree of severity of chronic ischemia of the  lower  limb arteries atherosclerotic lesions  does not correlate with  the  age factor, however, is closely  associated with  the  time  of admission of patients to the  hospital. Early treatment  for  medical patients with III and  IV degree of chronic lower  limb ischemia is associated with  the  presence of this  category of persons expressed pain  in the  legs  and  feet  and  trophic complications, pathogenetic link  which  is circulatory, and then cellular hypoxia, leading to cell death and  tissue up to the  development of focal necrosis. In the  structure of concomitant chronic lower  limb ischemia pathologies dominate diseases of the  cardiovascular system (coronary heart disease and  hypertension) in 100% of patients, nervous system diseases (encephalopathy) in 76,9% of patients, indicating that systematic, generalized atherosclerosis obliterans, which  is characterized by  involvement in  the  pathological process is not  only  lower  limb  arteries, and  distant arterial pools  of organs and  systems. It  has  been  shown that the  combined application of traditional preparations of basic therapy, intravenous infusions of ozonated saline  reopoliglyukina trentalom with  sulodexide and  shown to be highly effective in chronic critical limb ischemia therapy. Patients with  chronic obliterating atherosclerosis of the  arteries of the  lower  extremities is necessary to conduct a life-long therapy with  regular cardiovascular  hospitalizations not  less than 2 times a year for  routine preventive treatment.